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| From: | "G Stolwyk" <stolwyk@wave.co.nz> | 
| Date: | Sat, 29 Sep 2001 11:47:01 +1200 | 
| Readers, before proceeding, please read the 
Disclaimer in my previous post!  Thank you, Colin! I always appreciate a comment from a 
pharmacist! There is a large market for anti-TNF 
pharmaceuticals now. Below are comments from " Decision 
Resources, Inc." which reviews the commercial 
potential of novel agents in this field:  The TNF-Alpha Inhibitors in therapeutic products: " Etanercept "( 
Immmunex/Wyeth-Ayerst's Enbrel ), " Infliximab " ( 
Centocor/ Johnson@ Johnson's Remicade ) being used in the 
rheumatoid arthritis ( RA ) and inflammatory bowel disease( IBD). They predict that by 2010 approx. 37% of 
the anti-TNF market place will be attributed to sales in novel 
indications. Psoriasis and 
Psoriatic Arthritis trials are now in 
late-stage clinical development  and the TNF inhibitor will be the 
principal driver of growth in this market according to 
forecasts. Congestive Heart 
Failure ( CHF) This seems to be associated with high levels of 
TNF bio activity. This requires further study. Sepsis: A modest but definite 
beneficial effect by application of a refined anti- TNF product " 
Afelimomab " ( Knoll/Abbott's Segard ) in an improved clinical trial design, 
have been noted.   Yes, I have followed the TNF- Alpha Inhibitor 
market closely; it is showing great promise and profits are rising 
exponentially: It is a massive market!  This post and the previous one were mainly written 
for this site: This is the prime Australian Message Board on 
PTD.  I promised to do a summary of the status of 
PTD: See post 3241on that site. ( See also posts 340 and 1069 from the 
MMD Message Board). There are some principal contributors there and 
they are nice people to work with: these traders are a team and act 
accordingly.  Gerry | 
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