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| From: | "David Reid" <aspex@ix.net.nz> | 
| Date: | Wed, 8 Mar 2000 13:27:42 +1300 | 
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 GPG just goes to prove that being in the UK market 
does not guarantee performance. 
Now Sir Ron bemoans the fact that his share price 
is too low. 
Now on another tack entirely to show why I am in 
the UK market. 
This is not a tip but look at Provalis (PRO in UK 
/PVLS on NASDAQ) 
Bought by me at 20p and fell to 13p (poor timing) 
now 35.75p and $US 7.50 on NASDAQ at the close which is equivalent to 97p 
UK. 
Why did I buy? They were a struggling pharma 
developer in UK with a top product (oral insulin, I believe). They decided to 
give up on their own marketing team and farm out this. 
Why is the price rising? 
This comment from 16/3/99 announcement to the 
market. 
MacrulinTM - oral formulation of insulin for 
treatment of diabetes The development programme for this product is progressing 
to schedule and is maintaining its promise.  A series of clinical research 
studies is underway to confirm a commercial dosage form of the product from 
single dose studies in Type I diabetics and an initial multiple dose one-day 
study in Type 2 diabetics.  These studies will allow assessment of the 
likely clinical utility and indications to underpin the commercial potential of 
MacrulinTM.  The dosing is now complete and data are undergoing analysis. 
The preliminary analysis of the first Clamp study in Type I patients has 
demonstrated unequivocal evidence that the revised formulation of the product 
can deliver biologically active insulin in man through intestinal absorption. We 
expect to issue a further statement regarding this study in the second quarter 
of 1999. 
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